APADDICTO is a pilot study that evaluated the effect of a short 3-week program of physical activity (Barraud et al., in preparation). In this study, 52 patients with severe alcohol use disorder (sAUD) were offered adapted physical activity (APA) sessions starting from the withdrawal phase. An additional 35 sAUD patients received simple physical activity advice and open access to the gym. Both groups completed the same number of physical activity sessions, but the APA group had longer sessions. The dropout rate was 23.1% in the APA group and 31.4% in the free physical activity (FPA) group, which was not statistically significant. The various measured parameters (physical condition, impulsivity, self-esteem, anxiety, depression, and craving) improved in both groups, with no additional specific effect observed in the APA group. However, motivation to engage in physical activity increased in the APA group and decreased in the FPA group. We also conducted a literature review to examine the neurobiological criteria for adapting physical activity to patients (Cabé et al., 2022). Following this, we developed a tailored physical activity program, supervised by trained professionals (STAPS APAS), known as the APADDICTO program, which is currently ongoing. This program is offered at the beginning of hospitalization for detoxification and lasts for 12 weeks. Motivational support is provided. Measurements are taken at the start, at 6 weeks, and at 12 weeks to assess motivational factors and the program’s effectiveness. Patient feedback is used to modify and improve the program.