The Alcohol Use Disorder (AUD) research topic focuses on the effects of chronic and heavy alcohol consumption on brain and cognition. We are one of the few laboratories to investigate Korsakoff syndrome (KS), especially with neuroimaging techniques.
Our goal is twofold :
1 – To deepen our fundamental understanding of the pathophysiological mechanisms leading to alcohol-related cognitive deficits and brain abnormalities :
- Role of alcohol withdrawal, nutritional alterations, sleep disorders and liver dysfunction
- Temporal cascade of the different brain pathophysiological mechanisms leading to specific cognitive deficits
- Interaction between ageing and alcohol consumption
- Similarities and differences between AUD patients with and without KS
2 – To improve the clinical treatment of AUD patients with and without KS :
- Modifications of healthcare pathway or development of innovative treatment options for AUD patients with neuropsychological deficits
- Detection of AUD patients at risk to develop KS
We mainly use psychological, neuropsychological, biological, sleep and neuroimaging (structural MRI, DTI, resting-state fMRI, FDG-PET) examinations.
We are also engaged in the development of new methods to better evaluate the effects of AUD and we recently set-up a biobank (COBIOM) to prospectively collect blood of AUD patients at treatment entry.