The ALCOBRAIN project was conducted from 2012 to 2015 and included 36 patients recently detoxified with severe AUD, 11 patients with Korsakoff Syndrome and 29 healthy controls. All participants completed clinical and alcohol-related variables, a detailed neuropsychological assessment, biological measures and multimodal neuroimaging examinations (anatomical MRI, DTI and resting-state fMRI sequence).

From 2015 to 2019, an ancillary study called ALCOSLEEP was conducted and included 22 recently detoxified patients with severe AUD, 9 patients with Korsakoff syndrome and 20 healthy controls. In addition to the ALCOBRAIN examinations, the originality of this project was to carry out both subjective (questionnaires and sleep diaries) and objective (continuous actimetry recording during one week and one night of polysomnography) sleep measures. Patients with sAUD were followed up for one year with cognitive, brain and sleep examinations.